The Garrett lab is interested in how developing neurons use cell-surface recognition molecules called cell adhesion molecules (CAMs) during neural circuit formation. Our focus is on the process of self-avoidance, which prevents sister neurites from the same cell (“self”) and from cells of the same type (“homotypic”) from becoming entangled with each other. Our model is the mouse retina, where both self- and homotypic-avoidance is important for the orderly organization of the ~100 distinct types of neurons that process visual information.
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